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Image: Atypical mitosis

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Description: Stomach cancer precursor lesion. Micrograph of gastric mucosa with high grade dysplasia. H&E stain. Three clearly identifiable mitoses are seen. The one at the 12:00 o'clock position is tripolar, i.e. atypical. The mitoses at 3:00 o'clock and 6:00 o'clock are normal. Acute (neutrophils) and chronic (plasma cells, lymphocytes) inflammatory cells are in the lamina propria immediately underneath of the dysplastic epithelium. Atypical mitoses are a characteristic of precancerous lesions, i.e. dysplasia, and malignancy, i.e. cancer.
Title: Atypical mitosis
Credit: Own work
Author: Nephron
Usage Terms: Creative Commons Attribution-Share Alike 3.0
License: CC BY-SA 3.0
License Link: http://creativecommons.org/licenses/by-sa/3.0
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