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Image: Chromophobe renal cell carcinoma, eosinophilic variant - high mag

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Description: High magnification micrograph of chromophobe renal cell carcinoma, oncocytic variant. H&E stain. The features of chromophobe renal cell carcinoma (ChRCC) are: Pale staining cytoplasm. Periphery of cells distinct. Perinuclear clearing. The oncocytic variant of ChRCC, seen above, has eosinophilic cytoplasm. The term (ChRCC oncocytic variant), etymologically, may seem self-contradictory, to readers familiar with the fact that oncocytes have eosinophilic cytoplasm; chromophobe means colour-fearing, i.e. something that does not readily take-up dyes. The main differential diagnosis is renal oncocytoma, which like the oncocytic ChRCC has oncocytic cytoplasm, but lack perinuclear clear and has bland nuclei.
Title: Chromophobe renal cell carcinoma, eosinophilic variant - high mag
Credit: Own work
Author: Nephron
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License: CC BY-SA 3.0
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