Image: Fpubh-08-00383-g004

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Description: The association between SARS-CoV-2 and the Renin-Angiotensin-Aldosterone System (RAAS). SARS-CoV-2 binds to ACE2 receptor and enters into the cell. It has been hypothesized that this process leads to down-regulation of surface ACE2, resulting in unopposed angiotensin II buildup and activity, leading to a pro-inflammatory cascade. Alternative hypotheses are further described in the text. The uncertainties regarding the role of ACE-Is and ARBs in COVID-19 are also discussed. Ang, angiotensin; ACE, angiotensin-converting enzyme; AT1, angiotensin II type 1
Title: Fpubh-08-00383-g004
Credit: Chams N, Chams S, Badran R, Shams A, Araji A, Raad M, Mukhopadhyay S, Stroberg E, Duval EJ, Barton LM and Hajj Hussein I (2020) COVID-19: A Multidisciplinary Review. Front. Public Health 8:383. https://doi.org/10.3389/fpubh.2020.00383
Author: Nour Chams, Sana Chams, Reina Badran, Ali Shams, Abdallah Araji, Mohamad Raad, Sanjay Mukhopadhyay, Edana Stroberg, Eric J. Duval, Lisa M. Barton, and Inaya Hajj Hussein
Usage Terms: Creative Commons Attribution 4.0
License: CC BY 4.0
License Link: https://creativecommons.org/licenses/by/4.0
Attribution Required?: Yes

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