Image: Journal.ppat.1009372.g001

Description: Distribution of cGAMP nucleases across poxvirus species and genera. A representative maximum-likelihood phylogenetic tree for the Poxviridae family was generated from a multiple sequence alignment of the DNA-dependent RNA polymerase subunit 147 kDa protein (RPO147, J6R) from reference species, colour-coded according to their current classification. Accession numbers were as follows: vaccinia virus, AY243312; horsepox virus, DQ792504; variola virus, X69198; monkeypox virus, AY603973; camelpox virus, AF438165; ectromelia virus, NC_004105; cowpox virus, NC_003663; akhmeta virus, MH607143; volepox virus, KU749311; skunkpox virus, KU749310; raccoonpox virus, KP143769; NY poxvirus, MF001305; Murmansk poxvirus, MF001304; Yoka poxvirus, HQ849551; eptesipox virus, NC_035460; hypsugopox virus, MK860688; sheeppox virus, NC_004002; goatpox virus, AY077835; lumpy skin disease virus, AF409137; rabbit fibroma virus, AF170722; myxoma virus, AF170726; BeAn virus, KY094066; Cotia virus, KM595078; swinepox virus, AF410153; deerpox virus, AY689436; white tailed deer poxvirus, MF966153; moosepox virus, MG751778; Yaba monkey tumor virus, AY386371; tanapox virus, EF420156; cetacean poxvirus, MN653921; orf virus, AY386264; pseudocowpox virus, NC_013804; seal parapox virus, KY382358; bovine papular stomatitis virus, AY386265; red deer parapox virus, KM502564; sea otter poxvirus, MH427217; pteropox virus, KU980965; eastern grey kangaroo poxvirus, MF661791; western grey kangaroo poxvirus, MF467280; molluscum contagiosum virus 1, NC_001731; molluscum contagiosum virus 2, MH320549; flamingopox virus, MF678796; penguinpox virus, KJ859677; fowlpox virus, AF198100; canarypox virus, AY318871; turkeypox virus, KP728110; saltwater crocodile poxvirus 1, MG450915; saltwater crocodile poxvirus 2, MG450916; Nile crocodile poxvirus, DQ356948; salmon gill poxvirus, KT159937; C. rosaceana entomopox virus, HF679133; C. biennis entomopox virus, HF679132; A. moorei entomopox virus, AF250284; A. honmai entomopox virus, HF679131; M. separata entomopox virus, HF679134; A. cuprea entonomopox virus, AP013055; M. sanguinipes entomopox virus, NC_001993. Sequences were manually retrieved and aligned using Molecular Evolutionary Genetics Analysis (MEGA) package. This multiple sequence alignment was used to construct the phylogenetic tree. The presence of poxin in a lineage is indicated by coloured branches and a solid black box on the right-hand side. The presence of a Slfn domain is indicated by a solid grey box next to the poxin box. Empty boxes indicate gene inactivation (defined by the presence of at least one premature STOP codon truncating the predicted open reading frame).
Title: Journal.ppat.1009372.g001
Credit: Maluquer de Motes C (2021) Poxvirus cGAMP nucleases: Clues and mysteries from a stolen gene. PLoS Pathog 17(3): e1009372. https://doi.org/10.1371/journal.ppat.1009372
Author: Carlos Maluquer de Motes
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License: CC BY 4.0
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