Image: Schematic visualization of endocytic routes adopted by various GPI-Anchored proteins and other endocytic markers

Description: Schematic visualization of endocytic routes adopted by various GPI-Anchored proteins and other endocytic markers. A) Various membrane resident proteins and lipids like FR-GPI, prions, LRP, uPAR, cholesterol, sphingolipids and cholera-toxin bound to GM1 are present in a diffuse distribution in the plasma membrane. B) GPI-APs like FR-GPI align with cholesterol and sphingolipids to form lateral aggregates termed as rafts. uPAR and prion proteins, although GPI-anchored, interact with LRP and are endocytosed into the clathrin-coated pits. The interaction of the protein domains of uPAR and Prion with LRP seems to override the influence of the lateral segregation into rafts mediated by the GPI-anchor of these proteins. LRP has signal sequences in the cytoplasmic domain for recruitment into clathrin-coated pits. C and D) Raft-included markers like FR-GPI and cholera toxin bound to GM1 are endocytosed into GEECs whereas uPAR:LRP and prion;LRP complexes are endocytosed into vacuoles derived from clathrin-coated pits. Lakhan et al. Journal of Biomedical Science 2009 16:93 doi:10.1186/1423-0127-16-93
Title: Schematic visualization of endocytic routes adopted by various GPI-Anchored proteins and other endocytic markers
Credit: Endocytosis of glycosylphosphatidylinositol-anchored proteins
Author: Shaheen E Lakhan , Shefali Sabharanjak and Ananya De
Permission: © 2009 Lakhan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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