Image: 14 Hegasy Cas9 3D Complex Wiki E CCBYSA

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Description: 3D Structure of the CRISPR-Cas9 Interference Complex. 3D models are based on crystallization data using PDB sequence 4OO8. 1A: Structure of Cas9 protein. REC lobe (recognition) and NUC lobe (nuclease) are indicated as well as functional domains PI (PAM interacting), HNH, and RuvC. 1B: Abstract depiction of Cas9. 2A: Conformation of crRNA, tracrRNA, and DNA. 2B: Abstract depiction of molecules is shown in 2A. 3A: 3D structure of the complete interference complex. The NUC lobe is shown semi-transparent for clarity. 3B: Abstract depiction of the interference complex.
Title: 14 Hegasy Cas9 3D Complex Wiki E CCBYSA
Credit: Own work
Author: Guido4
Usage Terms: Creative Commons Attribution-Share Alike 4.0
License: CC BY-SA 4.0
License Link: https://creativecommons.org/licenses/by-sa/4.0
Attribution Required?: Yes

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CRISPR

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