Image: Ultrastructural analysis of the nuclear envelope in fibroblasts from the subject with HGPS (progeria)

Description: Ultrastructural analysis of the nuclear envelope in fibroblasts from the subject with HGPS. Low magnification transmission electron microscopic image of a passage 10 PT001 nucleus showed several herniations (a). Two higher-magnification images of the same nucleus at sites of blebs (b and c) showed a close apposition of the chromatin to the nuclear envelope. In a, b, and c the nucleus is to the left. Scale bars correspond to 2 μm in panel a, and 500 nm in panels b and c. Paradisi et al. BMC Cell Biology 2005 6:27 doi:10.1186/1471-2121-6-27
Title: Ultrastructural analysis of the nuclear envelope in fibroblasts from the subject with HGPS (progeria)
Credit: Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress
Author: Mauro Paradisi , Dayle McClintock , Revekka L Boguslavsky , Christina Pedicelli1 , Howard J Worman and Karima Djabali
Permission: © 2005 Paradisi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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