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Charles Brenner
Born (1961-10-30)October 30, 1961
Nationality USA
Alma mater Wesleyan University (B.A.)
Stanford University (Ph.D)
Brandeis University (Post-Doctoral)
Known for Discovery and characterization of nicotinamide riboside as a vitamin
Awards William E.M. Lands Lectureship
Fellow of the American Association for the Advancement of Science
Beckman Young Investigators Award
Basil O'Connor Award from the March of Dimes Birth Defects Foundation
New Investigator Award in the Pharmacological Sciences from the Burroughs Wellcome Fund
ASBMB Award for Exemplary Contributions to Education
Mary Swartz Rose Senior Investigator Award from the American Society for Nutrition
Scientific career
Fields Enzymology
Metabolism
Institutions City of Hope National Medical Center
University of Iowa
Dartmouth Medical School
Thomas Jefferson University
Thesis Specificity and Activity of the Kex2 Protease: From Yeast Genetics to Enzyme Kinetics (1993)
Doctoral advisor Robert S. Fuller
Other academic advisors Gregory A. Petsko
Dagmar Ringe
Influences Arthur Kornberg

Charles Brenner, born on October 30, 1961, is a leading scientist. He currently leads a special department at the Beckman Research Institute of the City of Hope National Medical Center. This department studies how our bodies use energy and how that relates to diseases like diabetes and cancer.

Dr. Brenner is famous for his work on a very important molecule called nicotinamide adenine dinucleotide, or NAD+. He made a big discovery: he found out how our bodies can turn something called nicotinamide riboside (NR) into NAD+. This discovery showed that NR is a new type of vitamin.

Who is Charles Brenner?

Charles Brenner is an American scientist. He specializes in enzymology and metabolism. Enzymology is the study of enzymes, which are proteins that help chemical reactions happen in our bodies. Metabolism is the study of how our bodies use food for energy and growth.

He has worked at several important universities and research centers. These include the University of Iowa and Dartmouth Medical School. His research has greatly helped us understand how our cells work.

What is NAD+?

NAD+ is a molecule found in every cell of your body. Think of it like a tiny energy helper. It plays a key role in many important processes. These include turning food into energy and repairing damaged cells.

Without enough NAD+, our cells can't work properly. This can affect our health and how we age. Scientists are very interested in NAD+ because it's so vital for life.

Discovering Nicotinamide Riboside (NR)

Before Dr. Brenner's work, scientists knew about other forms of vitamin B3. These forms could also help make NAD+. But Dr. Brenner discovered a new way our bodies make NAD+.

He found that cells can use nicotinamide riboside (NR) to create NAD+. This was a big deal! It meant that NR acts like a vitamin. It helps our bodies get the NAD+ they need. This discovery opened up new ways to think about health and nutrition.

How NR Becomes NAD+

Dr. Brenner's research showed a specific pathway. This pathway is like a step-by-step process. In this process, our cells take NR and change it into NAD+. This pathway is called the "eukaryotic nicotinamide riboside (NR) kinase pathway."

This discovery was important for understanding cell energy. It also showed how certain nutrients can support our health.

Why is NR Important?

Since Dr. Brenner's discovery, many studies have looked at NR. Scientists are exploring how NR might help with different health issues. These include supporting healthy aging and improving cell function.

Because of his work, NR is now recognized as a valuable nutrient. It can be found in some foods and is also available as a supplement.

His Career and Awards

Dr. Brenner studied at Wesleyan University and Stanford University. He earned his Ph.D. from Stanford. After that, he did more research at Brandeis University.

Throughout his career, Dr. Brenner has received many honors. He was named a Fellow of the American Association for the Advancement of Science. He also received the Beckman Young Investigators Award. These awards recognize his important contributions to science and education.

His work continues to influence how we understand metabolism and nutrition.

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