Fixed Dose Procedure facts for kids
FDP uses 10-20 animals to find the dose that produces toxicity signs but not death, and from there predicts the lethal dose. LD50 ("lethal dose 50%") uses 60-80 animals to find a dose that kills 50% of animals in a given time. FDP sometimes needs retesting using slightly higher or lower doses.
Fixed Dose Procedure Facts for Kids. Kiddle Encyclopedia.