Gunda Georg facts for kids
Gunda I. Georg is a chemist who is currently the Professor and Head of the Department of Medicinal Chemistry, Regents Professor, McKnight Presidential Chair, Robert Vince Endowed Chair at University of Minnesota and a former Co-Editor-in-Chief of American Chemical Society's Journal of Medicinal Chemistry. Her research interests are total synthesis and semisynthesis as well as evaluating biologically active agents. A cited expert in her field, she was elected to the American Association for the Advancement of Science in 1996 and inducted in the Medicinal Chemistry Hall of Fame in 2017. In 2019, she was announced as the 2020 winner and first woman to receive the Alfred Burger Award in Medicinal Chemistry (established by GlaxoSmithKline, now sponsored by Gilead). Dr Georg also works with her research groups to conduct research on Alzheimer's disease, epilepsy and cancer experimental therapeutics.
Education
She earned her B.S. in 1975 and Ph.D. in 1980 from Philipps Universitat Marburg.
Career
She co-authored a book with Lednicer and Mitscher (RIP). Her medical contributions include polishing off Gamendazole, Lonidamine and Pregnenolyne derivatives.
Selected publications
- Hawkinson, J. E.; Sinville, R.; Mudaliar, D.; Shetty, J.; Ward, T.; Herr, J. C.; Georg, G. I. Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2). ChemMedChem 2017. .
- Ayoub, A.; Hawk, M. L.; Herzig, R. J.; Wisniewski, A. J.; Gee, C. Zhu, J.-Y.; Berndt, N.; Scott, T. G.; Qi, J.; Jun, Q.; Bradner, J. E.; Ward, T. R.; Schönbrunn, E.; Georg, G. I.; Pomerantz, W. C. K. BET Bromodomain Inhibitors with One-step Synthesis Discovered from a Virtual Screen. J. Med. Chem. 2017, 60, 4805–4817.
- Patil, S.; Lis, L. G.; Schumacher, R. J.; Norris, B. J.; Morgan, M. L.; Cuellar, R. A. D.; Blazar, B. R.; Suryanarayanan, R.; Gurvich, V. J.; Georg, G. I. Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon adenocarcinoma and Ovarian Cancer. J. Med. Chem. 2015, 58, 9334–9344.
- Syeda, S. S.; Jakkaraj, S.; Georg, G. I. Scalable synthesis of the BET bromodomain inhibitor JQ1. Tetrahedron Lett. 2015, 56, 3454–3457.
- Coulup, S. K.; Huang, D. S.; Wong, H. L.; Georg, G. I. Identification of the Metabolic Profile of the α-Tubulin-binding Natural Product (-)-Pironetin. J. Med. Chem. 2019, 62, 1684–1689.
- Jakkaraj, S. R.; Young, V. G.; Georg, G. I. Syntheses of PDE3A Inhibitor ORG9935 and Determination of the Absolute Stereochemistries of its Enantiomers by X-ray Crystallography. Tetrahedron 2018, 74, 2769–2774.
- Paulson,C. N.; Guan,X.; Ayoub,A. M.; Chan, A.; Karim, R. M.; Pomerantz,W. K. C.; Schönbrunn, E.; Georg,G. I.; Hawkinson, J. E.Design, Synthesis and Characterization of a Pan-BET Fluorescent Polarization Bromodomain Probe. ACS Med. Chem. Lett. 2018, 9, 1223–12229.
