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sphincter of Oddi
Interior of the descending portion of the duodenum, showing bile papilla
Latin m. sphincter ampullae

The sphincter of Oddi (also hepatopancreatic sphincter or Glisson's sphincter), abbreviated as SO, is a muscular valve that in some animals, including humans, controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. It is named after Ruggero Oddi. The sphincter of Oddi is relaxed by a hormone via vasoactive intestinal peptide.

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