Butylphthalide facts for kids

Quick facts for kids Butylphthalide
Preferred IUPAC name 3-Butyl-2-benzofuran-1(3H)-one
Other names	3-Butylphthalide; 3-n-Butylphthalide
Identifiers
Abbreviations	NBP; BuPh
CAS number	6066-49-5
PubChem	61361
SMILES	O=C1OC(c2ccccc12)CCCC
InChI InChI=1/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-7,11H,2-3,8H2,1H3
Properties
Molecular formula	C12H14O2
Molar mass	190.23 g mol-1
Appearance	clear oily liquid
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Butylphthalide (3-n-butylphthalide or NBP) is one of the chemical constituents in celery oil, along with sedanolide, which is primarily responsible for the aroma and taste of celery.

Studies in animal models suggest that butylphthalide may be useful for the treatment of hypertension and may have neuroprotective effects. In 2002, NBP was approved in China for the treatment of cerebral ischemia.

NBP undergoes extensive metabolism in humans. The major metabolites in human plasma were 3-OH-NBP, 10-OH-NBP, 10-CO-NBP, 11-COOH-NBP. The AUC of metabolites was much larger than that of NBP.

Minor side effects were observed in preclinical and clinical studies. The minor bioactivation pathway of NBP was proved to be mediated via sulfation of 3-OH-NBP.