Pyletown is an unincorporated community in Stoddard County, in the U.S. state of Missouri.
A variant name was "Pyle". A post office called Pyle was established in 1895, and remained in operation until 1905. The community was named after J. K. Pyle, a local merchant.
Coordinates: 36°43′29″N 90°01′07″W / 36.72472°N 90.01861°W