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Cortisone
Cortison.svg
Cortisone-3D-balls.png
IUPAC name (8S,9S,10R,13S,14S,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
Other names 17α,21-Dihydroxypregn-4-ene-3,11,20-trione; 17α,21-Dihydroxy-11-ketoprogesterone; 17α-Hydroxy-11-dehydrocorticosterone
Identifiers
CAS number 53-06-5
PubChem 222786
KEGG D07749
MeSH Cortisone
ChEBI CHEBI:16962
SMILES O=C(CO)[C@@]3(O)CC[C@H]2[C@@H]4CC\C1=C\C(=O)CC[C@]1(C)[C@H]4C(=O)C[C@@]23C
Properties
Molecular formula C21H28O5
Molar mass 360.42 g mol-1
Melting point

220 to 224 °C, Expression error: Unrecognized word "to". K, Expression error: Unrecognized word "to". °F

Pharmacology
ATC code
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Cortisone is a 21-carbon steroid hormone. Its chemical name is 17-hydroxy-11-dehydrocorticosterone. It is one of the main hormones released by the adrenal gland in response to stress.

In chemical structure, it is closely related to cortisol. It is used to treat a variety of ailments and can be administered in various ways. Cortisone suppresses the immune system. This reduces inflammation, pain and swelling at the site of the injury. Long-term use of cortisone has risks.

Tadeus Reichstein, E.C. Kendall and P.S. Hench were awarded the Nobel Prize in Physiology or Medicine in 1950 for their discovery of cortisone.

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