Marys Home originally developed in the 1880s around the St. Mary's Roman Catholic Church. The church and community are named after the Virgin Mary. A post office was established as Mary's Home in 1884, and remained in operation until it was discontinued in 1918.
The P.A. Sanning Store was added to the National Register of Historic Places in 2005.
Marys Home, Missouri Facts for Kids. Kiddle Encyclopedia.