Wolff–Kishner reduction facts for kids

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The Wolff–Kishner reduction is an organic process of reducing carbonyl groups; usually ketones and aldehydes to alkanes. It is carried out in presence of solvent to speed up reaction. It is carried out in basic medium. Thus, it can not be used for base sensitive reagents. It is named after by Nikolai Kischner and Ludwig Wolff.

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Scheme 1. Wolff-Kishner Reduction
Scheme 1-1. Summary of mechanism of Wolff-Kishner reaction
Scheme 2. Kishner's conditions
Scheme 3. Wolff's conditions
Scheme 4. Mechanism of the Wolff-Kishner reduction
Scheme 5. Huang Minlon modification
Scheme 6. Barton modification
Scheme 7. Cram modification
Scheme 8. Caglioti modification
Scheme 11. Unsuccessful substrate in Caglioti reaction
Scheme 12-1. Deoxygenation of an α,β-unsaturated carbonyl compound
Scheme 12-2. Deoxygenation of an α,β-unsaturated carbonyl compound
Scheme 13. Mechanism of allylic diazene rearrangement
Scheme 14. Myers modification
Scheme 15. Azine formation
Scheme 16. Kishner-Leonard elimination
Scheme 18. Synthsesis of Aspidospermidine
Scheme 19. Reduction of a twisted amide
Scheme 20. Synthesis of sec-credenol
Scheme 21. Large-scale application
Scheme 22. Allylic diazene rearrangement

See also

In Spanish: Reducción de Wolff-Kishner para niños

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