David Bruce (microbiologist) facts for kids
Quick facts for kids
Major-General Sir David Bruce
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| Born | 29 May 1855 Melbourne, Australia
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| Died | 27 November 1931 (aged 76) London, England
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| Citizenship | British |
| Education | University of Edinburgh |
| Known for | trypanosome |
| Awards | Cameron Prize for Therapeutics of the University of Edinburgh (1899) Royal Medal (1904) Leeuwenhoek Medal (1915) Buchanan Medal (1922) Albert Medal (1923) Manson Medal (1923) |
| Scientific career | |
| Fields | Microbiology |
Major-General Sir David Bruce KCB FRS FRCP FRSE (29 May 1855 – 27 November 1931) was a Scottish pathologist and microbiologist who made some of the key contributions in tropical medicine. In 1887, he discovered a bacterium, now called Brucella, that caused what was known as Malta fever. In 1894, he discovered a protozoan parasite, named Trypanosoma brucei, as the causative pathogen of nagana (animal trypanosomiasis).
Working in the Army Medical Services and the Royal Army Medical Corps, Bruce's major scientific collaborator was his microbiologist wife Mary Elizabeth Bruce (née Steele), with whom he published around thirty technical papers out of his 172 papers. In 1886, he was chairman of the Malta Fever Commission that investigated the deadly disease, by which he identified a specific bacterium as the cause. Later, with his wife, he investigated an outbreak of animal disease called nagana in Zululand and discovered the protozoan parasite responsible for it. He led the second and third Sleeping Sickness Commission organised by the Royal Society that investigated an epidemic of human sleeping sickness in Uganda, where he established that tsetse fly was the carrier (vector) of these human and animal diseases.
The bacterium, Brucella, and the disease it caused, brucellosis, along with the protozoan Trypanosoma brucei, are named in his honour.
Contents
Biography
Early life and education
Bruce was born in Melbourne, Australia, to Scottish parents, engineer David Bruce (from Airth) and his wife Jane Russell Hamilton (from Stirling), who had emigrated to Australia in the gold rush of 1850. He was an only child. He returned with his family to Scotland at the age of five. They lived at 1 Victoria Square in Stirling. He was educated at Stirling High School and in 1869 began an apprenticeship in Manchester. However, a bout of pneumonia forced him to abandon this and re-assess his career. He then decided to study zoology but later changed to medicine at the University of Edinburgh in 1876. He graduated in 1881.
Medical career
After a brief period as a general practitioner in Reigate, Surrey (1881–83), where he met and married his wife Mary, he entered the Army Medical School in Hampshire at the Royal Victoria Hospital, Netley. He passed the military examination in 1883 and joined the Army Medical Services (in which he served until 1919). For his first post he joined the Royal Army Medical Corps in 1884 and was stationed in Valletta, Malta.
Bruce was appointed assistant professor of pathology at the Army Medical School in Netley in 1889, and served there for five years. He returned to military field service in 1894 and was posted to Pietermaritzburg, Natal, South Africa. He was assigned to investigate the case of cattle and horse sickness (called nagana) in Zululand. On 27 October 1894, he and his wife (Mary Elizabeth) moved to Ubombo Hill, where the disease was most prevalent. When the Second Boer War broke out in 1899, accompanied by his wife, he ran the field hospital during the Siege of Ladysmith (2 November 1899 until 28 February 1900). For his service during the war he was promoted to Lieutenant-Colonel. In 1899, Bruce was awarded the Cameron Prize for Therapeutics of the University of Edinburgh. In 1900, he joined the army commission investigating dysentery in military camps, at the same time working for the Royal Society's Sleeping Sickness Commission.
Bruce served as a member of the Army Medical Service Advisory Board from 1902 to 1911. In 1914 he became Commander of the Royal Army Medical College at Millbank, London, the position he held until his retirement as a Major-General in 1919. He was immediately appointed chairman of the governing body of the Lister Institute. During his career he published more than ninety-seven technical articles, of which about thirty were co-authored by his wife.
Death
He died four days after his wife in 1931, during her memorial service. Both were cremated in London and their ashes are buried together in Valley Cemetery in Stirling, close to Stirling Castle, beneath a simple stone cross on the east side of the main north–south path, near the southern roundel. They had no children.
Scientific contributions
Malta fever
At the time of Bruce's service in Malta, British soldiers suffered an outbreak of what was called the Malta fever. ..... It is transmitted by goat milk. In 1886, Bruce led the Malta Fever Commission that investigated the epidemic. Between 1886 and 1887, he studied five patients having Malta fever who died of the disease. Bruce's assistant, Surgeon Captain Matthew Louis Hughes named the disease "undulant fever" and the bacterium, Micrococcus melitensis. The source of the infection was not clear, Hughes believing it to come from soil and the bacterium inhaled from the air. He was correct in his prediction that it was only in 1905 goat milk was established as the source of the infection. The discovery that the disease was transmitted from goat milk was generally attributed to Bruce himself. But an analysis of historical record in 2005 revealed that Themistocles Zammit, one of the members of the commission, was the one who experimentally demonstrated the origin of the bacterium from goat milk.
The genus Micrococcus was changed to Brucella in honour of Bruce and is accepted as a valid name. Accordingly, the disease has been renamed brucellosis.
The fly disease and sleeping sickness
When Bruce was transferred to South Africa, he was sent to Zululand to investigate the outbreak of animal disease which the natives called nagana, and the Europeans, the fly disease. In 1894, he and his wife found that the disease was prevalent among cattle, donkey, horses and dogs. He also made accurate identification characters of the parasite as unique organisms:He performed several experiments on different animals as to how the parasite was transmitted. He found that the tsetse fly (Glossina morsitans), which was common in the region, could carry the live parasites from feeding on blood of the animals. He established that "the Tsetse Fly plays a most important part in the propagation of the disease", but was unable show that the flies could actually transmit the disease. Henry George Plimmer and John Rose Bradford gave the full description of the new parasite in 1899 as Trypanosoma brucei, the name after the discoverer.
The Sleeping Sickness Commission
There was an outbreak of sleeping sickness in Uganda from 1900. By 1901, it became severe with death toll estimated to about 20,000. More than 250,000 people died in the epidemic that lasted for two decades. The disease commonly popularised as "negro lethargy" was not known to be related to the fly disease. At the time, the human disease was believed to be either bacterial infection or helminth infection.
The Royal Society constituted a three-member Sleeping Sickness Commission in 1902 to investigate the epidemic. Led by George Carmichael Low from the London School of Hygiene and Tropical Medicine, the team included his colleague Aldo Castellani and Cuthbert Christy, a medical officer on duty in Bombay, India. The expedition was a failure as they found that bacteria or helminths were not involved in the disease.
The second Commission in 1902 was entrusted to Bruce, assisted by David Nunes Nabarro from the University College Hospital. By August 1903, Bruce and his team established that the disease was transmitted the tsetse fly, Glossina palpalis. The relationship with the fly disease in animals became obvious. In the third Commission (1908–1912) Bruce and his colleagues established the complete developmental stages of the trypanosome in tsetse fly.
Honours and awards
Bruce was elected a Fellow of the Royal Society (FRS) in 1899. He served as editor of the Journal of the Royal Army Medical Corps between 1904 and 1908. He was the recipient of the Cameron prize of Edinburgh University in 1901. He received the Royal Society's Royal Medal in 1904, the Mary Kingsley Medal in 1905, and the Stewart prize of the British Medical Association. He was Croonian lecturer at the Royal College of Physicians in 1915. He was awarded the Leeuwenhoek Medal in 1915, created a Companion of the Bath (CB) in the 1905 Birthday Honours, knighted in 1908 and upgraded to a Knight Commander of the Bath (KCB) in 1918. He was president of the British Science Association during 1924–1925.
Bruce's name features on the frieze of the London School of Hygiene & Tropical Medicine. Twenty-three names of public health and tropical medicine pioneers were chosen to feature on the School building in Keppel Street when it was constructed in 1926.
Bruce was nominated 31 times for the Nobel Prize in Physiology or Medicine between 1904 and 1932 for his discoveries in trypanosomiasis, but was never selected.
