Methysticin facts for kids
Quick facts for kids Methysticin |
|
---|---|
Preferred IUPAC name
(6R)-6-[(E)-2-(2H-1,3-Benzodioxol-5-yl)ethen-1-yl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
|
|
Identifiers | |
CAS number | |
PubChem | |
KEGG | C09952 |
SMILES | COC1=CC(=O)O[C@H](C1)/C=C/C2=CC3=C(C=C2)OCO3 |
InChI
InChI=1/C15H14O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h2-6,8,11H,7,9H2,1H3/b4-2+/t11-/m0/s1
|
|
Properties | |
Molecular formula | C15H14O5 |
Molar mass | 274.24 g mol-1 |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
Methysticin is one of the six major kavalactones found in the kava plant. Research suggests that methysticin and the related compound dihydromethysticin have CYP1A1 inducing effects which may be responsible for their toxicity.
Toxicity
Methysticin induces the function of the hepatic enzyme CYP1A1. This enzyme is involved in the toxification of benzo[a]pyrene into (+)-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, a highly carcinogenic substance. Another related compound is dihydromethysticin, which also induces the function of CYP1A1. No report so far has described enhancement of CYP1A1 expression in animals or humans in vivo from any constituent of kava.
All content from Kiddle encyclopedia articles (including the article images and facts) can be freely used under Attribution-ShareAlike license, unless stated otherwise. Cite this article:
Methysticin Facts for Kids. Kiddle Encyclopedia.