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Tracy Sonneborn
Born 19 October 1905 Edit this on Wikidata
Baltimore Edit this on Wikidata
Died 26 January 1981 Edit this on Wikidata (aged 75)
Bloomington Edit this on Wikidata
Alma mater
Employer
Awards
  • Kimber Genetics Award (1959)
  • Foreign Member of the Royal Society (1964) Edit this on Wikidata

Tracy Morton Sonneborn (born October 19, 1905, died January 26, 1981) was an American biologist. He spent his life studying tiny, single-celled creatures called protozoa, especially a type called Paramecium. He was also a Foreign Member of the Royal Society.

Early Life and Education

Tracy Sonneborn grew up in Baltimore, Maryland. He went to Baltimore City Public Schools and finished high school at Baltimore City College in 1922. When he was younger, Tracy was very interested in subjects like history and literature. He even thought about becoming a rabbi.

However, after taking a biology class with a teacher named E. A. Andrews, his interest in science grew much stronger. He then went to Johns Hopkins University, where he earned his first degree in 1925. He continued his studies there and received his Ph.D. in 1928. His advanced research focused on a small flatworm called Stenostomum.

Career in Science

After finishing his Ph.D., Sonneborn continued his research at Johns Hopkins University. From 1928 to 1929, he studied a tiny organism called Colpidium. He worked as a research assistant and associate at Johns Hopkins until 1939.

In 1939, he was offered a job at Indiana University. He became an associate professor there and later a full professor in 1943. He was recognized as a distinguished service professor in 1953 and retired in 1976.

Sonneborn was elected to several important scientific groups. These included the United States National Academy of Sciences in 1946, the American Academy of Arts and Sciences in 1949, and the American Philosophical Society in 1952. These honors showed how important his work was in the scientific community.

Discoveries in Genetics

Sonneborn was very good at observing tiny living things. He was also deeply interested in how cells, genes, and whole organisms work. After his early work on the Stenostomum worm, he started studying ciliated protozoa, especially Paramecium aurelia.

Understanding Paramecium Breeding

In 1937, Sonneborn made a big discovery about Paramecium. He found out how to control their breeding behavior by identifying different "mating types." This was a huge step because it allowed scientists to study how traits were passed down in these tiny creatures. He wrote important books, "Methods in the general biology and genetics of Paramecium aurelia" (1950) and "Methods in Paramecium research" (1970). These books helped many other scientists in their own research.

Genes, Cells, and Environment

Sonneborn was very interested in how genes, the cytoplasm (the jelly-like substance inside a cell), and the environment all work together to control what a cell inherits. He was the first to show that animals could inherit traits through the cytoplasm, not just through genes in the nucleus.

He studied something called the "kappa" factor in the cytoplasm. He found that tiny parts inside the cell, like mitochondria, chloroplasts, and even these "kappa particles," have their own DNA. These parts are passed down when a cell divides. If a new trait appeared because of one of these rare particles, only the new cells that got that specific part of the cytoplasm would inherit the trait.

Killer Traits in Paramecium

Sonneborn also discovered "killer traits" in Paramecium. Some Paramecium could produce toxins (poisons) that would harm other types of Paramecium, but not their own. He showed that certain genes in the nucleus were needed for this killer trait to continue. But the trait also depended on the "kappa" factor in the cytoplasm. Without kappa, the Paramecium would become sensitive to the toxin.

He also found different "serotypes" in Paramecium. Each serotype was linked to a specific gene and had a unique way of expressing itself.

Plasmagene Theory and Cytotaxis

Sonneborn developed the "plasmagene theory." This idea suggested that genes create something that can reproduce itself in the cytoplasm during normal cell division. However, this self-reproducing entity would be lost during sexual reproduction. Later, other scientists found that the "kappa" factor was actually a type of symbiotic bacteria living inside the Paramecium. This discovery showed that the plasmagene theory was not entirely correct.

Sonneborn then realized that the cytoplasm only passed information between the old and new parts of the cell's nucleus, rather than being a source of self-reproducing genes.

He then studied the outer structure of Paramecium, called the cortex. He showed that the existing structure of the cell's surface guides how new structures are formed. He called this phenomenon cytotaxis. This was a new idea in genetics, showing that how a cell is built can influence what it passes on.

Cilia Movement

Sonneborn also did experiments on how the cilia (tiny hair-like structures) of Paramecium move together. These cilia move in a coordinated way, like dancers, helping the single-celled organism swim. Sonneborn carefully rotated a small piece of the cell wall by 180 degrees. He found that this rotated section of cilia continued to wave in the direction it had before the surgery. This meant it was now waving in the opposite direction to the other cilia. When the Paramecium divided, its daughter cells would show the same unusual waving pattern if the rotated section was part of their new cell.

Sonneborn as a Teacher

Tracy Sonneborn was known as a very creative and inspiring teacher. He taught a course called "Heredity, Evolution and Society." This class explored the science of genetics and how new discoveries in that field could affect society.

One of his most popular lessons involved students acting out the process of protein synthesis. In this process, the genetic code is used to build proteins step-by-step. His excitement for science was contagious. His lectures encouraged many students to study protozoa and algae, just like he did.

Personal Life

Tracy Sonneborn married Ruth Meyers in 1929. Ruth was trained as a social worker, but she focused on supporting her husband's scientific career. They had two sons: Lee (who became a mathematician) and David (who became a biologist).

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