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Xiaowei Zhuang
庄小威
Born (1972-01-21) January 21, 1972 (age 53)
Rugao, Jiangsu, China
Education Suzhou High School
University of Science and Technology of China
University of California, Berkeley
Known for Stochastic Optical Reconstruction Microscopy (STORM)
Awards MacArthur Fellows Program(2003)
ACS Award in Pure Chemistry(2007)
Max Delbruck Prize(2010)
Sackler Prize(2011)
NAS Award in Molecular Biology(2015)
Breakthrough Prize in Life Sciences(2019)
Vilcek Prize in Biomedical Science(2020)
Heinrich Wieland Prize(2022)
Scientific career
Fields Biophysics
Institutions Harvard University
Howard Hughes Medical Institute
Doctoral students Melike Lakadamyali

Xiaowei Zhuang (simplified Chinese: 庄小威; traditional Chinese: 莊小威; pinyin: Zhuāng Xiǎowēi) was born in January 1972. She is a famous Chinese-American biophysicist. A biophysicist studies living things using the rules of physics.

She is a professor at Harvard University and also works at the Howard Hughes Medical Institute. She is best known for inventing a special way to see tiny things. This method is called Stochastic Optical Reconstruction Microscopy (STORM).

STORM is a super-resolution microscope. It helps scientists see things inside living cells that are too small for regular microscopes. For her work, she won the 2019 Breakthrough Prize in Life Sciences.

Early Life and School

Xiaowei Zhuang's parents were both professors. Her father, Zhuang Lixian, and her mother, Zhu Renzhi, taught at the University of Science and Technology of China (USTC).

Xiaowei Zhuang also went to the USTC. She earned her first degree in Physics in 1991. Later, she got her Ph.D. in Physics from the University of California, Berkeley in 1996.

After her Ph.D., she worked as a researcher at Stanford University from 1997 to 2001. In 2001, she started teaching at Harvard University. She became a full professor there in 2006. In 2005, she also became an Investigator at the Howard Hughes Medical Institute.

Amazing Discoveries

Professor Zhuang's lab created STORM. This is a special type of microscope that uses single molecules. It helps scientists see things in super high detail.

Seeing in 3D with STORM

Her lab showed that STORM can create 3D images. This means they could see tiny cell parts in three dimensions. They also found special dyes that glow brightly. These dyes helped make STORM images even clearer.

What STORM Helps Us See

Using STORM, Professor Zhuang and her team have studied many different living things. They looked at tiny single-celled organisms and even complex parts of the brain.

These studies led to exciting discoveries. For example, they found new structures in nerve cells. These structures are like tiny skeletons inside the axons of neurons. Axons are the long parts of nerve cells that send signals.

New Ways to Study Cells

Professor Zhuang's lab also invented MERFISH. This is a method to image many different RNA types in single cells. RNA is like a messenger that carries instructions in cells. MERFISH helps scientists see where these instructions are and how many there are.

Her team also developed ways to track single viruses. This helps them understand how viruses interact with cells. They also use a method called single-molecule FRET to study tiny parts of living cells.

Awards and Recognitions

Professor Zhuang has received many important awards for her scientific work. These awards recognize her amazing discoveries and inventions.

  • 2022: Heinrich Wieland Prize
  • 2021: Lurie Prize in Biomedical Sciences
  • 2020: Vilcek Foundation Prize in Biomedical Science
  • 2019: Pearl Meister Greengard Prize
  • 2019: NAS Award for Scientific Discovery
  • 2019: Breakthrough Prize in Life Sciences
  • 2018: Dr. H.P. Heineken Prize for Biochemistry and Biophysics, Royal Netherlands Academy of Arts and Sciences
  • 2018: Pittsburgh Analytical Chemistry Award
  • 2017: Honorary doctorate, Delft University of Technology
  • 2017: Lennart Nilsson Award, Karolinska Institute, Sweden
  • 2016: Doctor of Philosophy Honoris Causa, Stockholm University
  • 2015: Foreign academician of the Chinese Academy of Sciences
  • 2015: NAS Award in Molecular Biology
  • 2013: Member American Academy of Arts and Sciences
  • 2012: Member National Academy of Sciences
  • 2012: Fellow American Physical Society
  • 2012: Fellow American Association for the Advancement of Science
  • 2011: Sackler Prize
  • 2010: Max Delbruck Prize
  • 2008: Coblentz Award
  • 2007: ACS Award in Pure Chemistry
  • 2004: Sloan Fellowship
  • 2003: Packard Fellowship
  • 2003: MacArthur Fellows Program
  • 2003: Beckman Young Investigators Award
  • 2021: Great Immigrants Award honored by the Carnegie Corporation of New York

See also

Kids robot.svg In Spanish: Xiaowei Zhuang para niños

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