Lake Cherokee is an unincorporated community and census-designated place (CDP) in Gregg and Rusk counties, Texas, United States. Its population was 3,071 as of the 2010 census.
The community consists of housing development that surrounds Lake Cherokee, a reservoir on Cherokee Bayou, an east-flowing tributary of the Sabine River. Texas State Highway 149 forms the northern border of the CDP; the highway leads northwest 12 miles (19 km) to Longview and southeast 24 miles (39 km) to Carthage.
According to the U.S. Census Bureau, the community has an area of 16.525 square miles (42.80 km2); 12.239 square miles (31.70 km2) of its area is land, and 4.286 square miles (11.10 km2) is water. About three-quarters of the area of the CDP is within Rusk County, with the remainder in Gregg County. The county line follows the center of the lake for the lower half of its reach. The upstream half of the lake is entirely within Rusk County.