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Andrew Wakefield
Andrew Wakefield with Justyna Socha Warsaw 2019.jpg
Wakefield at an anti-vaccine rally in Warsaw, Poland in June 2019
Born
Andrew Jeremy Wakefield

(1956-09-03) 3 September 1956 (age 67)
Canadian Red Cross Memorial Hospital, Taplow, Buckinghamshire, England
Education King Edward's School, Bath
Alma mater St Mary's Hospital Medical School, London
Occupation Former physician, anti-vaccination activist
Known for Lancet MMR autism fraud
Spouse(s) Carmel, m. 32 years, divorced
Partner(s) Elle Macpherson (2017–2019)
Children 4


Andrew Jeremy Wakefield (born 3 September 1956) is a British fraudster, discredited academic, anti-vaccine activist, and former physician.

He was struck off the medical register for his involvement in The Lancet MMR autism fraud, a 1998 study that fraudulently claimed a link between the measles, mumps, and rubella (MMR) vaccine and autism. He has subsequently become known for anti-vaccination activism. Publicity around it caused a sharp decline in vaccination uptake, leading to a number of outbreaks of measles around the world and many deaths therefrom. He was a surgeon on the liver transplant programme at the Royal Free Hospital in London and became senior lecturer and honorary consultant in experimental gastroenterology at the Royal Free and University College School of Medicine. He resigned from his positions there in 2001, "by mutual agreement", then moved to the United States. In 2004, Wakefield co-founded and began working at the Thoughtful House research center (now renamed Johnson Center for Child Health and Development) in Austin, Texas, serving as executive director there until February 2010, when he resigned in the wake of findings against him by the British General Medical Council.

Wakefield published his 1998 paper on autism in the prestigious medical journal The Lancet, claiming to have identified a novel form of enterocolitis linked to autism. However, other researchers were unable to reproduce his findings, and a 2004 investigation by Sunday Times reporter Brian Deer identified undisclosed financial conflicts of interest on Wakefield's part. Wakefield reportedly stood to earn up to $43 million per year selling test kits. Most of Wakefield's co-authors then withdrew their support for the study's interpretations, and the General Medical Council (GMC) conducted an inquiry into allegations of misconduct against Wakefield and two former colleagues, focusing on Deer's findings.

In 2010, the GMC found that Wakefield had been dishonest in his research, had acted against his patients' best interests and mistreated developmentally delayed children, and had "failed in his duties as a responsible consultant". The Lancet fully retracted Wakefield's 1998 publication on the basis of the GMC's findings, noting that elements of the manuscript had been falsified and that the journal had been "deceived" by Wakefield. Three months later, Wakefield was struck off the UK medical register, in part for his deliberate falsification of research published in The Lancet, and was barred from practising medicine in the UK. In a related legal decision, a British court held that "[t]here is now no respectable body of opinion which supports [Wakefield's] hypothesis, that MMR vaccine and autism/enterocolitis are causally linked". In 2016, Wakefield directed the anti-vaccination film Vaxxed: From Cover-Up to Catastrophe.

Early life and education

Wakefield was born on 3 September 1956, to Graham Wakefield, a neurologist, and Bridget d'Estouteville Matthews, a general practitioner, at the Canadian Red Cross Memorial Hospital. As a student at the independent King Edward's School, Bath, he was captain of his local rugby team.

After leaving King Edward's School, Wakefield studied medicine at St Mary's Hospital Medical School (now Imperial College School of Medicine), fully qualifying in 1981.

Wakefield became a fellow of the Royal College of Surgeons in 1985.

Career

At the University of Toronto from 1986 to 1989, he was a member of a team that studied tissue rejection problems with small intestine transplantation, using animal models. He continued his studies of small intestine transplantation under a Wellcome Trust travelling fellowship at University of Toronto in Canada.

Claims of measles virus–Crohn's disease link

Back in the UK, he worked on the liver transplant programme at the Royal Free Hospital in London. In 1993, Wakefield attracted professional attention when he published reports in which he concluded that measles virus might cause Crohn's disease; and two years later he published a paper in The Lancet proposing a link between the measles vaccine and Crohn's disease. Subsequent research failed to confirm this hypothesis, with a group of experts in Britain reviewing a number of peer-reviewed studies in 1998 and concluding that the measles virus did not cause Crohn's disease, and neither did the MMR vaccine.

Later, in 1995, while conducting research into Crohn's disease, he was approached by Rosemary Kessick, the parent of a child with autism, who was seeking help with her son's bowel problems and autism; Kessick ran a group called Allergy Induced Autism. In 1996, Wakefield turned his attention to researching possible connections between the MMR vaccine and autism.

At the time of his MMR research study, Wakefield was senior lecturer and honorary consultant in experimental gastroenterology at the Royal Free Hospital School of Medicine (from 2008, UCL Medical School). He resigned in 2001, by "mutual agreement and was made a fellow of the Royal College of Pathologists", and moved to the US in 2001 (or 2004, by another account). He was reportedly asked to leave the Royal Free Hospital after refusing a request to validate his 1998 Lancet paper with a controlled study.

Wakefield subsequently helped establish and served as the executive director of Thoughtful House Center for Children, which studies autism in Austin, Texas, where, according to The Times, he "continued to promote the theory of a link between the MMR vaccine and autism, despite admitting it was 'not proved'." He resigned from Thoughtful House in February 2010, after the British General Medical Council found that he had been "dishonest and irresponsible" in conducting his earlier autism research in England. The Times reported in May 2010 that he was a medical advisor for Visceral, a UK charity that "researches bowel disease and developmental disorders".

Wakefield is barred from practising as a physician in the UK, and is not licensed in the US. He lives in the US where he has a following, including the anti-vaccinationist Jenny McCarthy, who wrote the foreword for Wakefield's autobiography, Callous Disregard. She has a son with autism-like symptoms that she believes were caused by the MMR vaccine. According to Deer, as of 2011, Wakefield lives near Austin with his family.

Wakefield has set up the non-profit Strategic Autism Initiative to commission studies into the condition, and is currently listed as a director of a company called Medical Interventions for Autism and another called the Autism Media Channel.

The Lancet fraud

On 28 February 1998, Wakefield was the lead author of a study of twelve children with autism that was published in The Lancet. The study proposed a new syndrome called autistic enterocolitis, and raised the possibility of a link between a novel form of bowel disease, autism, and the MMR vaccine. The authors said that the parents of eight of the twelve children linked what were described as "behavioural symptoms" with MMR, and reported that the onset of these symptoms began within two weeks of MMR vaccination.

These possible triggers were reported as MMR in eight cases, and measles infection in one. The paper was instantly controversial, leading to widespread publicity in the UK and the convening of a special panel of the UK's Medical Research Council the following month. One 2005 study in Japan found that there was no causal relationship between the MMR vaccine and autism in groups of children given the triple MMR vaccine and children who received individual measles, mumps and rubella vaccinations. In Japan, the MMR vaccine had been replaced with individual vaccinations in 1993.

Although the paper said that no causal connection had been proven, before it was published, Wakefield made statements at a press conference and in a video news release issued by the hospital, calling for suspension of the triple MMR vaccine until more research could be done. This was later criticized as 'science by press conference'. According to BBC News, it was this press conference, rather than the paper in The Lancet, that fuelled the MMR vaccination scare. The BBC report said he told journalists: "it was a 'moral issue' and he could no longer support the continued use of the three-in-one jab for measles, mumps and rubella. 'Urgent further research is needed to determine whether MMR may give rise to this complication in a small number of people,' Wakefield said at the time." He said, "If you give three viruses together, three live viruses, then you potentially increase the risk of an adverse event occurring, particularly when one of those viruses influences the immune system in the way that measles does." He suggested parents should opt for single vaccinations against measles, mumps and rubella, separated by gaps of one year. 60 Minutes interviewed him in November 2000, and he repeated these claims to the U.S. audience, providing a new focus for the nascent anti-vaccination movement in the U.S., which had been primarily concerned about thiomersal in vaccines.

In December 2001, Wakefield resigned from the Royal Free Hospital, saying, "I have been asked to go because my research results are unpopular." The medical school said that he had left "by mutual agreement". In February 2002, Wakefield stated: "What precipitated this crisis was the removal of the single vaccine, the removal of choice, and that is what has caused the furore—because the doctors, the gurus, are treating the public as though they are some kind of moronic mass who cannot make an informed decision for themselves."

Wakefield v Channel 4 Television and Others

In November 2004, Channel 4 broadcast a one-hour Dispatches investigation by reporter Brian Deer; the Toronto Star said Deer had "produced documentary evidence that Wakefield applied for a patent on a single-jab measles vaccine before his campaign against the MMR vaccine, raising questions about his motives".

In addition to Wakefield's unpublished initial patent submission, Deer released a copy of the published patent application. At page 1, the first paragraph of this stated:

The present invention relates to a new vaccine/immunisation for the prevention and/or prophylaxis against measles virus infection and to a pharmaceutical or therapeutic composition for the treatment of IBD (Inflammatory Bowel Disease); particularly Crohn's Disease and Ulcerative Colitis and regressive behavioural disease (RBD).

Before describing the research in Wakefield's 1998 paper in The Lancet, at the same page this patent explicitly states that the use of the MMR vaccine causes autism:

It has now also been shown that use of the MMR vaccine (which is taken to include live attenuated measles vaccine virus, measles virus, mumps vaccine virus and rubella vaccine virus, and wild strains of the aforementioned viruses) results in ileal lymphoid nodular hyperplasia, chronic colitis and pervasive developmental disorder including autism (RBD), in some infants.

According to Deer, a letter from Wakefield's lawyers to him dated 31 January 2005 said: "Dr Wakefield did not plan a rival vaccine."

In the Dispatches programme, Deer also revealed that Nicholas Chadwick, a researcher working under Wakefield's supervision in the Royal Free medical school, had failed to find measles virus in the children reported on in The Lancet.

In January 2005, Wakefield initiated libel proceedings against Channel 4, the independent production company Twenty Twenty and Brian Deer, The Sunday Times, and against Deer personally along with his website briandeer.com in the case Wakefield v Channel Four Television and Others [2006] EWHC 3289 (QB); [2007] 94 BMLR 1. Within weeks of issuing his claims, however, Wakefield sought to have the action frozen until after the conclusion of General Medical Council proceedings against him. Channel 4 and Deer sought a High Court order compelling Wakefield to continue with his action, or discontinue it. After a hearing on 27 and 28 October 2005, Justice David Eady ruled against a stay of proceedings:

It thus appears that the Claimant wishes to use the existence of the libel proceedings for public relations purposes, and to deter other critics, while at the same time isolating himself from the "downside" of such litigation, in having to answer a substantial defence of justification ... I am quite satisfied, therefore, that the Claimant wished to extract whatever advantage he could from the existence of the proceedings while not wishing to progress them or to give the Defendants an opportunity of meeting the claims.

The judgment identified Channel 4's "very lengthy extracts" summarizing Deer's allegations against Wakefield:

(i) [Wakefield] spread fear that the MMR vaccine might lead to autism, even though he knew that his own laboratory had carried out tests whose results dramatically contradicted his claims in that the measles virus had not been found in a single one of the children concerned in his study and he knew or ought to have known that there was absolutely no basis at all for his belief that the MMR should be broken up into single vaccines.
(ii) In spreading such fear, acted dishonestly and for mercenary motives in that, although he improperly failed to disclose the fact, he planned a rival vaccine and products (such as a diagnostic kit based on his theory) that could have made his fortune
(iii) Gravely abused the children under his care by unethically carrying out extensive invasive procedures (on occasions requiring three people to hold a child down), thereby driving nurses to leave and causing his medical colleagues serious concern and unhappiness
(iv) Improperly and/or dishonestly failed to disclose to his colleagues and to the public that his research on autistic children had begun with a contract with solicitors who were trying to sue the manufacturers of the MMR vaccine
(v) Improperly or dishonestly lent his reputation to the International Child Development Resource Centre, which promoted to very vulnerable parents expensive products for whose efficacy (as he knew or should have known) there was no scientific evidence

Eady's ruling states that, "The views or conclusions of the GMC disciplinary body would not, so far as I can tell, be relevant or admissible", that Channel 4's allegations "go to undermine fundamentally the Claimant's professional integrity and honesty", and that, "It cannot seriously be suggested that priority should be given to GMC proceedings for the resolution of issues."

In December 2006, Deer released records obtained from the Legal Services Commission, showing that it had paid £435,643 in undisclosed fees to Wakefield for the purpose of building a case against the MMR vaccine. Those payments, The Sunday Times reported, had begun two years before publication of Wakefield's paper in The Lancet. Within days of Deer's report, Wakefield dropped all his libel actions and was ordered to pay all defendants' legal costs.

Other concerns

Wakefield's data was also questioned; a former graduate student, who appeared in Deer's programme, later testified that Wakefield ignored laboratory data that conflicted with his hypothesis. An independent investigation of a collaborating laboratory questioned the accuracy of the data underpinning Wakefield's claims.

In June 2005, the BBC programme Horizon reported on an unnamed and unpublished study of blood samples from a group of 100 autistic children and 200 children without autism. They reported finding 99% of the samples contained no trace of the measles virus, and the samples that did contain the virus were just as likely to be from non-autistic children, i.e., only three samples contained the measles virus, one from an autistic child and two from a typically developing child. The study's authors found no evidence of any link between MMR and autism.

The Institute of Medicine (IOM) of the United States National Academy of Sciences, along with the CDC and the UK National Health Service, have found no link between vaccines and autism. Reviews in the medical literature have also found no link between the MMR vaccine and autism or with bowel disease, which Wakefield called "autistic enterocolitis".

General Medical Council hearings

Between July 2007 and May 2010, a 217-day "fitness to practise" hearing of the UK General Medical Council examined charges of professional misconduct against Wakefield and two colleagues involved in the paper in The Lancet. The charges included that he:

  • "Was being paid to conduct the study by solicitors representing parents who believed their children had been harmed by MMR".
  • Ordered investigations "without the requisite paediatric qualifications" including colonoscopies, colon biopsies and lumbar punctures ("spinal taps") on his research subjects without the approval of his department's ethics board and contrary to the children's clinical interests, when these diagnostic tests were not indicated by the children's symptoms or medical history.
  • "Act[ed] 'dishonestly and irresponsibly' in failing to disclose ... how patients were recruited for the study" as well as in his descriptions in the Lancet papers and in questions after the paper published, about what ailments the children had, and when those ailments were observed relative to their getting vaccinated.
  • "Conduct[ed] the study on a basis not approved by the hospital's ethics committee."
  • Purchased blood samples—for £5 each—from children present at his son's birthday party, which Wakefield joked about in a later presentation.
  • "[S]howed callous disregard for any distress or pain the children might suffer"

Wakefield denied the charges; on 28 January 2010, the GMC ruled against Wakefield on all issues, stating that he had "failed in his duties as a responsible consultant", acted against the interests of his patients, and "dishonestly and irresponsibly" in his controversial research. On 24 May 2010, he was struck off the United Kingdom medical register. It was the harshest sanction that the GMC could impose, and effectively ended his career as a physician. In announcing the ruling, the GMC said that Wakefield had "brought the medical profession into disrepute", and no sanction short of erasing his name from the register was appropriate for the "serious and wide-ranging findings" of misconduct. On the same day, Wakefield's autobiography, Callous Disregard was published, using the same words as one of the charges against him ("he showed callous disregard for any distress or pain the children might suffer"). Wakefield argued that he had been unfairly treated by the medical and scientific establishment.

Fraud and conflict of interest allegations

In February 2009, The Sunday Times reported that a further investigation by the newspaper had revealed that Wakefield "changed and misreported results in his research, creating the appearance of a possible link with autism", citing evidence obtained by the newspaper from medical records and interviews with witnesses, and supported by evidence presented to the GMC.

In April 2010, Deer expanded on laboratory aspects of his findings in a report in the BMJ, recounting how normal clinical histopathology results (obtained from the Royal Free hospital) had been subjected to wholesale changes, from normal to abnormal, in the medical school and published in The Lancet. On 2 January 2011, Deer provided two tables comparing the data on the twelve children, showing the original hospital data and the data with the wholesale changes as used in the 1998 The Lancet article.

On 5 January 2011, BMJ published an article by Brian Deer entitled "How the case against the MMR vaccine was fixed". Deer said that, based on examination of the medical records of the 12 children in the original study, his research had found:

The paper in The Lancet was a case series of 12 child patients; it reported a proposed "new syndrome" of enterocolitis and regressive autism and associated this with MMR as an "apparent precipitating event." But in fact:

Three of nine children reported with regressive autism did not have autism diagnosed at all. Only one child clearly had regressive autism;

Despite the paper claiming that all 12 children were "previously normal", five had documented pre-existing developmental concerns;

Some children were reported to have experienced first behavioural symptoms within days of MMR, but the records documented these as starting some months after vaccination;

In nine cases, unremarkable colonic histopathology results—noting no or minimal fluctuations in inflammatory cell populations—were changed after a medical school "research review" to "non-specific colitis";

The parents of eight children were reported as blaming MMR, but 11 families made this allegation at the hospital. The exclusion of three allegations—all giving times to onset of problems in months—helped to create the appearance of a 14-day temporal link;

Patients were recruited through anti-MMR campaigners, and the study was commissioned and funded for planned litigation.

In an accompanying editorial, BMJ editors said:

Clear evidence of falsification of data should now close the door on this damaging vaccine scare ... Who perpetrated this fraud? There is no doubt that it was Wakefield. Is it possible that he was wrong, but not dishonest: that he was so incompetent that he was unable to fairly describe the project, or to report even one of the 12 children's cases accurately? No. A great deal of thought and effort must have gone into drafting the paper to achieve the results he wanted: the discrepancies all led in one direction; misreporting was gross. Moreover, although the scale of the GMC's 217-day hearing precluded additional charges focused directly on the fraud, the panel found him guilty of dishonesty concerning the study's admissions criteria, its funding by the Legal Aid Board, and his statements about it afterwards.

The British Medical Journal editorial concluded that Wakefield's paper was an "elaborate fraud".

In a BMJ follow-up article on 11 January 2011, Deer stated that Wakefield had planned to capitalize on the MMR vaccination scare provoked by his paper. He said that based upon documents he had obtained under Freedom of information legislation, Wakefield—in partnership with the father of one of the boys in the study—had planned to launch a venture on the back of an MMR vaccination scare that would profit from new medical tests and "litigation driven testing". The Washington Post reported that Deer said that Wakefield predicted he "could make more than $43 million a year from diagnostic kits" for the new condition, autistic enterocolitis. According to Deer's report in BMJ, the ventures, Immunospecifics Biotechnologies Ltd and Carmel Healthcare Ltd—named after Wakefield's wife—failed after Wakefield's superiors at University College London's medical school gave him a two-page letter that said:

We remain concerned about a possible serious conflict of interest between your academic employment by UCL, and your involvement with Carmel ... This concern arose originally because the company's business plan appears to depend on premature, scientifically unjustified publication of results, which do not conform to the rigorous academic and scientific standards that are generally expected.

WebMD reported on Deer's BMJ report, saying that the $43 million predicted yearly profits would come from marketing kits for "diagnosing patients with autism" and that "the initial market for the diagnostic will be litigation-driven testing of patients with AE [autistic enterocolitis, an unproven condition concocted by Wakefield] from both the UK and the US". According to WebMD, the BMJ article also claimed that Carmel Healthcare Ltd. would succeed in marketing products and developing a replacement vaccine if "public confidence in the MMR vaccine [were] damaged".

In October 2012, research published in PNAS, the Proceedings of the National Academy of Sciences, identified Wakefield's 1998 paper as the most cited retracted scientific paper, with 758 citations, and gave the "reason for retraction" as "fraud".

Journal retractions

On 2 February 2010, The Lancet formally retracted Wakefield's 1998 paper. The retraction states: "The claims in the original paper that children were 'consecutively referred' and that investigations were 'approved' by the local ethics committee have been proven to be false."

The following day, the editor of a specialist journal, NeuroToxicology, withdrew another Wakefield paper that was in press. The article, which concerned research on monkeys, had already been published online and sought to implicate vaccines in autism.

In May 2010, The American Journal of Gastroenterology retracted a paper of Wakefield's that used data from the 12 patients of the article in The Lancet.

On 5 January 2011, British Medical Journal editors recommended that Wakefield's other publications be scrutinized and retracted if need be.

Political activism

Wakefield was scheduled to testify before the Oregon Senate Health Care Committee on 9 March 2015, in opposition to Senate Bill 442, "a bill that would eliminate nonmedical exemptions from Oregon's school immunization law". The Oregon Chiropractic Association had invited him. The chairman of the committee then canceled the meeting "after it became clear that" Wakefield planned to testify. She denied that her decision had anything to do with Wakefield's plans.

On 24 April 2015, Wakefield received two standing ovations from the students at Life Chiropractic College West when he told them to oppose Senate Bill 277 (SB 277), a bill that proposes elimination of non-medical vaccine exemptions. Wakefield had previously been a featured speaker at a 2014 "California Jam" gathering of chiropractors, as well as a 2015 "California Jam" seminar, with continuing education credits, sponsored by Life Chiropractic College West. On 3 July 2015, Wakefield participated in a protest held in Santa Monica, California, against SB 277, a recently enacted bill which removed the personal belief exemption to school vaccine requirements in California state law.

Regarding his anti-vaccine advocacy, Wakefield has been described as a conspiracy theorist by ThinkProgress, The Washington Post, The Guardian, the Los Angeles Times, Wired, the Johns Hopkins Bloomberg School of Public Health, Steven Salzberg, and Paul Offit.

Vaxxed film

In 2016, Wakefield directed the anti-vaccination propaganda film Vaxxed: From Cover-Up to Catastrophe. The film purports to show "an appalling cover-up committed by the government agency charged with protecting the health of American citizens [the US Centers for Disease Control and Prevention (CDC)] ... an alarming deception that has contributed to the skyrocketing increase of autism and potentially the most catastrophic epidemic of our lifetime." The film was withdrawn from New York's 2016 Tribeca Film Festival after the festival's founder Robert De Niro (who has a child with autism) reversed his decision to include it. The film was also scheduled to be projected at the Mairie de Paris but was then moved to a small private cinema. Wakefield called this action censorship. Ian Lipkin, professor of epidemiology and director of the Center for Infection and Immunity at the Columbia University Mailman School of Public Health, writing in The Wall Street Journal, said: "If Vaxxed had been submitted as science fiction, it would merit attention for its story line, character development and dialogue. But as a documentary it misrepresents what science knows about autism, undermines public confidence in the safety and efficacy of vaccines, and attacks the integrity of legitimate scientists and public-health officials".

Selected publications

Journal articles

(Retracted, see , PubMed. If this is an intentional citation to a retracted paper, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)

(Erratum: , PubMed,  Retraction Watch. If the erratum has been checked and does not affect the cited material, please replace {{Erratum|...}} with {{Erratum|...|checked=yes}}.) (Retracted)

See also

Kids robot.svg In Spanish: Andrew Wakefield para niños

  • H. Hugh Fudenberg
  • List of scientific misconduct incidents
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