Desmethoxyyangonin facts for kids
Quick facts for kids Desmethoxyyangonin |
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Preferred IUPAC name
4-Methoxy-6-[(E)-2-phenylethen-1-yl]-2H-pyran-2-one
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| Other names | (E)-4-Methoxy-6-styryl-2H-pyran-2-one 5,6-Dehydrokavain 4-Methoxy-6-[(E)-2-phenylvinyl]-2-pyranone |
| Identifiers | |
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| PubChem | |
| SMILES | COC1=CC(=O)OC(=C1)C=CC2=CC=CC=C2 |
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InChI
InChI=1/C14H12O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-10H,1H3/b8-7+
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| Properties | |
| Molecular formula | C14H12O3 |
| Molar mass | 228.23 g mol-1 |
| Appearance | white to faint yellow powder |
| Density | 1.18 g/mL |
| Melting point |
148 °C, 421 K, 298 °F |
| Boiling point |
440 °C, 713 K, 824 °F |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
Desmethoxyyangonin or 5,6-dehydrokavain is one of the six main kavalactones found in the Piper methysticum (kava) plant.
Pharmacology
Desmethoxyyangonin is a reversible inhibitor of monoamine oxidase B (MAO-B). Kava is able to increase dopamine levels in the nucleus accumbens and desmethoxyyangonin likely contributes to this effect. This, along with several other catecholamines, may be responsible for the purported attention-promoting effects of kava.
Desmethoxyyangonin has marked activity on the induction of CYP3A23.
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Desmethoxyyangonin Facts for Kids. Kiddle Encyclopedia.