Desmethoxyyangonin facts for kids

Quick facts for kids Desmethoxyyangonin
Preferred IUPAC name 4-Methoxy-6-[(E)-2-phenylethen-1-yl]-2H-pyran-2-one
Other names	(E)-4-Methoxy-6-styryl-2H-pyran-2-one 5,6-Dehydrokavain 4-Methoxy-6-[(E)-2-phenylvinyl]-2-pyranone
Identifiers
CAS number	15345-89-8
PubChem	5273621
SMILES	COC1=CC(=O)OC(=C1)C=CC2=CC=CC=C2
InChI InChI=1/C14H12O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-10H,1H3/b8-7+
Properties
Molecular formula
Molar mass	0 g mol-1
Appearance	white to faint yellow powder
Density	1.18 g/mL
Melting point
Boiling point
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Desmethoxyyangonin or 5,6-dehydrokavain is one of the six main kavalactones found in the Piper methysticum (kava) plant.

Pharmacology

Desmethoxyyangonin is a reversible inhibitor of monoamine oxidase B (MAO-B). Kava is able to increase dopamine levels in the nucleus accumbens and desmethoxyyangonin likely contributes to this effect. This, along with several other catecholamines, may be responsible for the purported attention-promoting effects of kava.

Desmethoxyyangonin has marked activity on the induction of CYP3A23.