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Martha Vaughan (August 4, 1926 – September 13, 2018) was an American biochemist and psychologist. She worked at the National Heart Lung and Blood Institute (NHLBI) in Bethesda, Maryland. Vaughan was elected to the National Academy of Sciences in 1985. She was born in Chicago, Illinois.

Vaughan's work focused on cell signaling, cellular regulation, lipid metabolism, and the roles of key proteins dealing with cholera toxin and pertussis toxin.

Vaughan died on September 13, 2018 in Bethesda at the age of 92.

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