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Sir Peter John Ratcliffe, FRS, FMedSci (born 14 May 1954) is a British physician and scientist. He is trained as a nephrologist. He was a practicing clinician at the John Radcliffe Hospital, Oxford and Nuffield Professor of Clinical Medicine and head of the Nuffield Department of Clinical Medicine at the University of Oxford from 2004 to 2016.

In 2016 he became Clinical Research Director at the Francis Crick Institute, retaining a position at Oxford as member of the Ludwig Institute of Cancer Research and Director of the Target Discovery Institute, University of Oxford.

Ratcliffe was born in Morecambe, Lancashire.

Ratcliffe is best known for his work on cellular reactions to hypoxia, for which he shared the 2019 Nobel Prize in Physiology or Medicine with William Kaelin Jr. and Gregg L. Semenza.

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