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Alexander Sergeevich Spirin (Russian: Александр Сергеевич Спирин) (4 September 1931 – 30 December 2020) was a Russian biochemist. He was a Distinguished Professor at the Lomonosov Moscow State University. His works focused on nucleic acids and protein biosynthesis. In 1974 he was elected a Member of the German Academy of Sciences Leopoldina. He was elected a foreign associate of the US National Academy of Sciences in April 2019.

Spirin died on 30 December 2020 at the age of 89.

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