K. C. Nicolaou facts for kids
Quick facts for kids
K. C. Nicolaou
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Born | July 5, 1946 Karavas, Cyprus
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(age 78)
Alma mater | University College London |
Known for | Total synthesis Nicolaou Taxol total synthesis Corey–Nicolaou macrolactonization |
Awards | Ernest Guenther Award (1996) Wolf Prize in Chemistry (2016) |
Scientific career | |
Fields | Chemistry |
Institutions | Rice University Scripps Research Institute |
Doctoral students | Tushar Kanti Chakraborty |
Other notable students | Phil Baran Govindasamy Mugesh |
Kyriacos Costa Nicolaou (born July 5, 1946) is a famous chemist from Cyprus and America. He is known for his amazing work in making natural products in the lab. This process is called total synthesis. Natural products are special chemicals found in plants, animals, or tiny living things. They are often used to make medicines.
Professor Nicolaou is currently a chemistry professor at Rice University. Before this, he taught at other important places like The Scripps Research Institute and the University of Pennsylvania.
Contents
About K. C. Nicolaou
K. C. Nicolaou was born on July 5, 1946, in a place called Karavas in Cyprus. He grew up there and went to school until he was 18.
In 1964, he moved to England. He spent two years learning English and getting ready for university. He then studied chemistry at the University of London. He earned his first degree in 1969 and his Ph.D. (a very high degree) in 1972.
In 1972, he moved to the United States. He worked at Columbia University and Harvard University for a few years. After that, he joined the University of Pennsylvania as a chemistry professor.
His Work in San Diego and Singapore
In 1989, Professor Nicolaou moved to San Diego, California. There, he worked at two places at once: the University of California, San Diego and The Scripps Research Institute. He became a very important professor and even led the Chemistry Department at Scripps.
From 2005 to 2011, he also directed a special lab in Singapore. In 2013, he moved to Rice University, where he teaches today.
What His Research Group Does
Professor Nicolaou's team works in a field called organic chemistry. They focus on finding new ways to make complex molecules. Their main goal is to create many difficult molecules that are found in nature. This is what "total synthesis" means.
He is famous for making many complex natural molecules. Two well-known examples are Taxol and vancomycin.
- Taxol: This is a very important medicine used to fight cancer.
- Vancomycin: This is a powerful antibiotic used to treat serious infections.
In 1994, his team successfully made Taxol in the lab. This was a huge achievement because Taxol has a very complicated structure. It even made the news because of how hard it was to create!
Amazing Molecules He Has Made
Professor Nicolaou and his team have successfully created many complex natural molecules in the lab. This is a list of some of them:
- Endiandric acids A–D (1982)
- Amphoteronolide B and Amphotericin B (1987)
- Calicheamicin γ1 (1992)
- Sirolimus (1993)
- Taxol (1994)
- Zaragozic acid A (1994)
- Brevetoxin B (1995)
- Vancomycin (1998)
- Uncialamycin (2008)
- Sporolide B (2009)
- Viridicatumtoxin B (2013)
- Shishijimicin A (2015)
- Thailanstatin A (2016)
- Gukulenin B (2022)
Books He Has Written
Professor Nicolaou has also written or helped write several popular books about making molecules. These books are very helpful for other chemists.
- Classics in Total Synthesis I, 1996
- Classics in Total Synthesis II, 2003
- Classics in Total Synthesis III, 2011
He also wrote other books, including:
- Molecules That Changed the World, 2008
- Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials, 2002
- Selenium in Natural Products Synthesis, 1984
Awards and Honors
K. C. Nicolaou has received many important awards and honors for his work. These awards show how much his research has helped the world of chemistry.
- 2021 Robert Koch Gold Medal (Germany)
- 2016 Wolf Prize in Chemistry (Israel)
- 2011 Benjamin Franklin Medal in Chemistry (Franklin Institute USA)
- 2005 Arthur C. Cope Award (USA)
- 2003 Nobel Laureate Signature Award in Graduate Education (with Phil S. Baran)
- 2002 Tetrahedron Prize
- 2001 Ernst Schering Prize (Germany)
- 2000 Paul Karrer Gold Medal (Switzerland)
- 1998 Esselen Award (USA)
- 1996 Linus Pauling Award (USA)
- 1996 William H. Nichols Medal (USA)
- Aspirin Prize (Spain)
- Max Tishler Prize Lecture (Harvard)
- Yamada Prize (Japan)
- Janssen Prize (Belgium)
- Nagoya Medal (Japan)
- Centenary Medal (Royal Society UK)
- Inhoffen Medal (Germany)
- ACS Award for Creative Work in Synthetic Organic Chemistry (USA)
- ACS Guenther Award in Natural Products Chemistry (USA)
- Fellow of the American Academy of Arts and Sciences
- Member of the National Academy of Sciences
- Member of the American Philosophical Society
- Foreign Member of the Royal Society (2013)
- Several honorary degrees