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Cell nucleus facts for kids

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HeLa cells stained with Hoechst 33258
HeLa cells seen under a microscope. The blue parts are the nuclear DNA inside the nucleus.
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Cell biology
Animal cell diagram
Animal Cell.svg
Components of a typical animal cell:
  1. Nucleolus
  2. Nucleus
  3. Ribosome (dots as part of 5)
  4. Vesicle
  5. Rough endoplasmic reticulum
  6. Golgi apparatus (or, Golgi body)
  7. Cytoskeleton
  8. Smooth endoplasmic reticulum
  9. Mitochondrion
  10. Vacuole
  11. Cytosol (fluid that contains organelles; with which, comprises cytoplasm)
  12. Lysosome
  13. Centrosome
  14. Cell membrane

The cell nucleus (plural: nuclei) is a special part of a cell found in plants, animals, fungi, and humans. It acts like the "brain" or control center of the eukaryotic cell. While most cells have just one nucleus, some have many, and a few, like red blood cells, have none at all.

The main job of the nucleus is to keep the cell's genetic material, or DNA, safe. It controls everything the cell does by sending out instructions. The nucleus is wrapped in a double layer called the nuclear envelope, which separates the DNA from the rest of the cell.

Structure of the Nucleus

Diagram human cell nucleus
A diagram showing the parts of the nucleus. You can see the double membrane, the pores, the DNA, and the dark spot called the nucleolus.

The nucleus is usually the largest organelle in an animal cell. In humans, it is about six micrometres (μm) wide. It is made up of several important parts.

The Nuclear Envelope

Think of the nuclear envelope as a strong double wall that protects the precious DNA inside. It has two layers:

  • An inner membrane that faces the inside of the nucleus.
  • An outer membrane that faces the rest of the cell.

This envelope keeps the environment inside the nucleus different from the outside, which is important for protecting the genetic code.

Nuclear Pores

NuclearPore crop
A close-up drawing of a nuclear pore. It acts like a gate in the nuclear wall.

The nuclear envelope is not a solid wall. It has thousands of tiny holes called nuclear pores. These pores act like security gates.

  • Small molecules can pass through freely.
  • Large molecules, like proteins and RNA, need a special "ticket" to get in or out.

This system ensures that only the right materials enter the control center.

The Nucleolus

Micrograph of a cell nucleus
A real photo taken with an electron microscope. The dark, round spot is the nucleolus.

Inside the nucleus, you can often see a dark, dense spot called the nucleolus. It does not have a membrane around it. The nucleolus is a factory that builds parts for ribosomes. Ribosomes are the machines that make proteins for the cell. Once the ribosome parts are built here, they are sent out through the nuclear pores to start working in the main part of the cell.

Chromosomes and DNA

MouseChromosomeTerritoriesBMC Cell Biol6-44Fig2e
A mouse cell nucleus with DNA stained blue. Different chromosomes are highlighted in red and green.

The nucleus holds nearly all of the cell's genome. The genome is the complete set of instructions for building and operating the organism. These instructions are written in long strands of DNA.

If you stretched out the DNA from just one human cell, it would be about two meters long! To fit inside the tiny nucleus, the DNA is wrapped tightly around spools made of proteins called histones. This DNA-protein mixture is called chromatin.

  • Euchromatin: This is loosely packed DNA. It contains the instructions the cell uses often.
  • Heterochromatin: This is tightly packed DNA. It contains instructions the cell rarely uses.

When a cell gets ready to divide, the chromatin packs up even tighter into shapes called chromosomes.

What Does the Nucleus Do?

The nucleus has two main jobs: controlling the cell's activities and copying information.

Controlling the Cell

Basic diagram of a transcription factory during transcription
A diagram showing how the nucleus reads DNA to make RNA.

The nucleus controls the cell by regulating gene expression. This is like a chef deciding which recipe to cook from a massive cookbook.

  1. The nucleus finds the specific gene (recipe) needed.
  2. It makes a copy of that gene into a molecule called messenger RNA (mRNA). This process is called transcription.
  3. The mRNA is sent out of the nucleus to the ribosomes, which read the instructions and build the specific protein.

This allows the cell to react to its environment. For example, if you eat sugar, your cells' nuclei will send out instructions to make enzymes that digest sugar.

Copying Information

Before a cell divides to make a new cell, it must copy all of its DNA so the new cell gets a full set of instructions. This process is called DNA replication. The nucleus provides a safe place for this complex copying process to happen without errors.

Moving Things In and Out

RanGTPcycle
A diagram showing how energy is used to move things in and out of the nucleus.

Traffic in and out of the nucleus is very busy, but it is strictly controlled by the nuclear pores.

  • Going In: Proteins that work inside the nucleus (like the ones that help copy DNA) are made outside. They have a special code called a nuclear localization signal. Special carrier proteins called importins see this code and carry them through the gate.
  • Going Out: Messenger RNA and ribosome parts made inside the nucleus need to go out to the cytoplasm to do their work. Carrier proteins called exportins help them leave.

This transport requires energy, which comes from a molecule called GTP.

Other Parts Inside

Besides the nucleolus, there are other small structures inside the nucleus that help organize its work.

Cajal Bodies

Cajal-Body-Overview
A diagram of a Cajal body.

Cajal bodies are small, round structures found in the nucleus. They act like workshops where RNA is modified and prepared before it is used. They are named after Santiago Ramón y Cajal, the scientist who discovered them.

Speckles

Speckles are storage areas for "splicing factors." Splicing factors are tools the cell uses to edit RNA. When the cell needs to edit a lot of RNA, these factors move from the speckles to the location where the work is being done.

Cell Division

Mitosis-fluorescent
A cell dividing. The green lines are pulling the blue chromosomes apart.

When a cell divides (a process called mitosis), the nucleus usually breaks down temporarily.

  1. Disassembly: The nuclear envelope dissolves. This allows the duplicated chromosomes to be pulled apart to opposite sides of the cell.
  2. Reassembly: Once the chromosomes are separated, a new nuclear envelope forms around each set.
  3. Result: The cell splits in two, and each new cell has its own brand-new nucleus.

Some simple organisms, like yeast, do not break down their nucleus when they divide. Instead, the nucleus pinches in half.

Cells Without a Nucleus

Redbloodcells
Human red blood cells do not have a nucleus. This gives them their donut-like shape.

Not all cells have a single nucleus.

  • No Nucleus: Human red blood cells start with a nucleus but get rid of it as they mature. This creates more space to carry oxygen. Because they lack a nucleus, they cannot divide or repair themselves, so they only live for about 120 days.
  • Many Nuclei: Some cells, like osteoclasts (bone cells) and skeletal muscle cells, have multiple nuclei. This often happens when several smaller cells fuse together to form one giant cell.

Evolutionary Origins

Scientists are curious about how the nucleus first appeared. Simple cells like bacteria do not have a nucleus. There are a few main theories:

  • Symbiosis Theory: This idea suggests that a long time ago, a simple cell swallowed another type of cell (like a bacterium). Instead of digesting it, they started living together. The swallowed cell might have evolved into the nucleus.
  • Viral Theory: Some scientists think a large virus might have infected a simple cell and taken control, eventually becoming the nucleus.

History of Discovery

Leeuwenhoek1719RedBloodCells
Drawings from 1719 by Antonie van Leeuwenhoek. He was the first to draw the nucleus in red blood cells.
Flemming1882Tafel1Fig14
A drawing from 1882 showing chromosomes inside a nucleus.

The nucleus was the first organelle ever discovered.

  • 1719: Antonie van Leeuwenhoek, a pioneer of microscopy, drew pictures of salmon red blood cells and noticed a "lumen" (light spot) inside them.
  • 1831: Scottish botanist Robert Brown gave the nucleus its name. While looking at orchid flowers under a microscope, he saw an opaque spot in the cells and called it the "areola" or "nucleus."
  • 1870s: Scientists like Oscar Hertwig discovered that the nucleus plays a key role in reproduction. This helped prove that the nucleus carries the information needed to create new life.

See also

Kids robot.svg In Spanish: Núcleo celular para niños

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