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Neuron
Diagram of neuron

A neuron (or neurone) is a nerve cell that carries electrical impulses. Neurons are the basic units of our nervous system.

Neurons have a cell body (soma or cyton), dendrites and an axon. Dendrites and axons are nerve fibers. There are about 86 billion neurons in the human brain, which is about 10% of all brain cells. The human brain has about 16 billion neurons in the cerebral cortex. The neurons are supported by glial cells and astrocytes.

Neurons are connected to one another, but they do not actually touch each other. Instead they have tiny gaps called synapses. These gaps are chemical synapses or electrical synapses which pass the signal from one neuron to the next.

Types of neurons

Gyrus Dentatus 40x
Golgi-stained neurons in human hippocampal tissue

By connection

There are three classes of neurons: motor neurons, sensory neurons and interneurons.

By function

  • Sensory neurons carry signals from sense organs to the spinal cord and brain.
  • Relay neurons carry messages between sensory or motor neurons and the central nervous system
  • Motor neurons carry signals from the CNS to muscles, motor neurons are connected to the relay neurons. The signal passes between the neurons via synapses. Synapses are microscopic voids between cells where chemicals are released from the axon terminal of one cell to specialized chemical receptors on the dendrite of the receiving cell.

Cell division

Mature neurons never divide: that is the general rule. They do not undergo cell division. In most cases, neurons are generated by special types of stem cells. A type of glial cell, called astrocytes, have also been seen to turn into neurons. In humans, neurogenesis (the origin of new nerve cells) largely ceases during adulthood – but in two brain areas, the hippocampus and the olfactory bulb, there is strong evidence for substantial numbers of new neurons.

The largest part of the human brain by far is the neocortex. It has at least~1010 neurons which stay with us for life.

Nervous system

Anatomy of a Neuron with Synapse
Schematic of a single pyramidal neuron, the primary excitatory neuron of the cerebral cortex, with a synaptic connection from an incoming axon onto a dendritic spine

Neurons are the primary components of the nervous system, along with the glial cells that give them structural and metabolic support. The nervous system is made up of the central nervous system, which includes the brain and spinal cord, and the peripheral nervous system, which includes the autonomic, enteric and somatic nervous systems. In vertebrates, the majority of neurons belong to the central nervous system, but some reside in peripheral ganglia, and many sensory neurons are situated in sensory organs such as the retina and cochlea.

Axons may bundle into nerve fascicles that make up the nerves in the peripheral nervous system (like strands of wire that make up a cable). In the central nervous system bundles of axons are called nerve tracts.

Neurons in the brain

The number of neurons in the brain varies dramatically from species to species. In a human, there are an estimated 10–20 billion neurons in the cerebral cortex and 55–70 billion neurons in the cerebellum. By contrast, the nematode worm Caenorhabditis elegans has just 302 neurons, making it an ideal model organism as scientists have been able to map all of its neurons. The fruit fly Drosophila melanogaster, a common subject in biological experiments, has around 100,000 neurons and exhibits many complex behaviors. Many properties of neurons, from the type of neurotransmitters used to ion channel composition, are maintained across species, allowing scientists to study processes occurring in more complex organisms in much simpler experimental systems.

History

Golgi Hippocampus
Drawing by Camillo Golgi of a hippocampus stained using the silver nitrate method
Purkinje cell by Cajal
Drawing of a Purkinje cell in the cerebellar cortex done by Santiago Ramón y Cajal, demonstrating the ability of Golgi's staining method to reveal fine detail

The neuron's place as the primary functional unit of the nervous system was first recognized in the late 19th century through the work of the Spanish anatomist Santiago Ramón y Cajal.

To make the structure of individual neurons visible, Ramón y Cajal improved a silver staining process that had been developed by Camillo Golgi.

In 1888 Ramón y Cajal published a paper about the bird cerebellum. In this paper, he stated that he could not find evidence for anastomosis between axons and dendrites and called each nervous element "an absolutely autonomous canton." This became known as the neuron doctrine, one of the central tenets of modern neuroscience.

In 1891, the German anatomist Heinrich Wilhelm Waldeyer wrote a highly influential review of the neuron doctrine in which he introduced the term neuron to describe the anatomical and physiological unit of the nervous system.

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Kids robot.svg In Spanish: Neurona para niños

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